We did not create our products without rigorous scientific research. We hired a medical doctor to assist us in research and development of Isavera products. Below is a list of studies we referenced to help determine the material, temperature and method of action of our products. Please note that our wraps have not been a part of a medical study.


  1. Selective Cryolysis: A Novel Method of Non-invasive Fat Removal
  2. Cryolipolysis for Noninvasive Fat Cell Destruction: Initial Results from a Pig Model
  3. Cryolipolysis for Reduction of Arm Fat: Safety and Efficacy of a Prototype Coolcup Applicator with Flat Contour
  4. A Prospective Clinical Study of Noninvasive Cryolipolysis™ for Subcutaneous Fat Layer Reduction
  5. Cryolipolysis Versus Laser Lipolysis on Adolescent Abdominal Adiposity
  6. Synergistic Effects of Cryolipolysis and Shock Waves for Noninvasive Body Contouring
  7. Paradoxical Adipose Hyperplasia and Cellular Effects after Cryolipolysis: A Case Report
  8. Clinical Efficacy of Non-invasive Cryolipolysis and Its Effects on Peripheral Nerves
  9. Clinical Effectiveness of Non-invasive Selective Cryolipolysis
  10. Multiple Same Day Cryolipolysis Treatments for the Reduction of Subcutaneous Fat Are Safe and Do Not Affect Serum Lipid Levels or Liver Function Tests
  11. A Cautious but Optimistic Opinion of Submental Cryolipolysisi
  12. Safety and Efficacy of Bilateral Submental Cryolipolysis with Quantified 3-dimensional Imaging of Fat Reduction and Skin Tightening
  13. Frostbite Following Cryolipolysis Treatment in a Beauty Salon: A Case Study
  14. Cryolipolysis for Nonsurgical Reduction of Fat in the Lateral Chest Wall Post-mastectomy
  15. Skin Necrosis of the Thigh after a Cryolipolysis Session: A Case Report
  16. Prospective Internally Controlled Blind Reviewed Clinical Evaluation of Cryolipolysis Combined with Multipolar Radiofrequency and Varipulse Technology for Enhanced Subject Results in Circumferential Fat Reduction and Skin Laxity of the Flanks
  17. Simulation of Cryolipolysis as a Novel Method for Noninvasive Fat Layer Reduction
  18. Effects of Cryolipolysis on Abdominal Adiposity
  19. Cryolipolysis – Scientific Background of a Current Hype in Aesthetic Medicine
  20. Non-invasive Tumescent Cryolipolysis Using a New 4D Handpiece: A Comparative Study with a Porcine Model
  21. Men at Risk for Paradoxical Adipose Hyperplasia after Cryolipolysis
  22. Long-term Efficacy Follow-up on Two Cryolipolysis Case Studies: 6 and 9 Years Post-treatment
  23. Prototype Coolcup Cryolipolysis Applicator with over 40% Reduced Treatment Time Demonstrates Equivalent Safety and Efficacy with Greater Patient Preference
  24. A Case of Motor Neuropathy after Cryolipolysis of the Arm
  25. Non-invasive Cryolipolysis to Reduce Subcutaneous Fat in the Arms
  26. Safety and Efficacy of Cryolipolysis for Non-invasive Reduction of Submental Fat
  27. Delayed Onset Pain Associated with Cryolipolysis Treatment: A Retrospective Study with Treatment Recommendations
  28. Male Body Contouring
  29. Adipose Hypertrophy Following Cryolipolysis
  30. Ultrasound Cavitation Versus Cryolipolysis for Non-invasive Body Contouring
  31. Cryolipolysis for Targeted Fat Reduction and Improved Appearance of the Enlarged Male Breast
  32. The Efficacy of Cryolipolysis Treatment on Arms and Inner Thighs
  33. Transient Alterations of Cutaneous Sensory Nerve Function by Noninvasive Cryolipolysis
  34. Paradoxical Adipose Hyperplasia Secondary to Cryolipolysis: An Underreported Entity?
  35. The Safety and Efficacy of Cryolipolysis: A Systematic Review of Available Literature
  36. Cryolipolysis: The Importance of Scientific Evaluation of a New Technique
  37. Non-invasive Subcutaneous Fat Reduction: A Review
  38. FDA MAUDE Data on Complications with Lasers, Light Sources, and Energy-based Devices
  39. Cryolipolysis for Safe and Effective Inner Thigh Fat Reduction
  40. Cryolipolysis Conformable-surface Applicator for Nonsurgical Fat Reduction in Lateral Thighs
  41. A Review of the Aesthetic Treatment of Abdominal Subcutaneous Adipose Tissue: Background, Implications, and Therapeutic Options
  42. Cryolipolysis and Skin Tightening
  43. Non-invasive Fat Reduction of the Flanks Using a New Cryolipolysis Applicator and Overlapping, Two-cycle Treatments
  44. Cryolipolysis in Aesthetic Plastic Surgery
  45. Improved Methods for Selective Cryolipolysis Results in Subcutaneous Fat Layer Reduction in a Porcine Model
  46. Fat Reduction in the Inner Thigh Using a Prototype Cryolipolysis Applicator
  47. Does Cryolipolysis Lead to Skin Tightening? A First Report of Cryodermadstringo
  48. An Evaluation of the Patient Population for Aesthetic Treatments Targeting Abdominal Subcutaneous Adipose Tissue
  49. Noninvasive Selective Cryolipolysis and Reperfusion Recovery for Localized Natural Fat Reduction and Contouring
  50. Three-dimensional Volumetric Quantification of Fat Loss Following Cryolipolysis
  51. Paradoxical Adipose Hyperplasia after Cryolipolysis
  52. Enhanced Clinical Outcome with Manual Massage Following Cryolipolysis Treatment: A 4-month Study of Safety and Efficacy
  53. Cryolipolysis: A Historical Perspective and Current Clinical Practice
  54. Broad Overview of a Clinical and Commercial Experience with Coolsculpting
  55. Longitudinal Evaluation of Cryolipolysis Efficacy: Two Case Studies
  56. Safety, Tolerance, and Patient Satisfaction with Noninvasive Cryolipolysis
  57. Non-invasive Cryolipolysis for Body Contouring in Chinese–a First Commercial Experience
  58. Noninvasive Body Contouring with Radiofrequency, Ultrasound, Cryolipolysis, and Low-level Laser Therapy
  59. Cryolipolysis for Reduction of Excess Adipose Tissue
  60. Cryolipolysis for Subcutaneous Fat Layer Reduction
  61. Non-invasive Cryolipolysis for Subcutaneous Fat Reduction Does Not Affect Serum Lipid Levels or Liver Function Tests
  62. Clinical Efficacy of Noninvasive Cryolipolysis and Its Effects on Peripheral Nerves
  63. Cryolipolysis for Fat Reduction and Body Contouring: Safety and Efficacy of Current Treatment Paradigms
  64. Transient Alterations of Cutaneous Sensory Nerve Function by Non-invasive Cryolipolysis
  65. Pre and Post Lipocryolysis Thermic Conditioning Enhances Rat Adipocyte Destruction
  66. Non-invasive Cryolipolysis™ for Subcutaneous Fat Reduction Does Not Affect Serum Lipid Levels or Liver Function Tests
  67. Selective Cryolysis: A Novel Method Of Non-invasive Fat Removal
  68. Broad Overview of a Clinical & Commercial Experience with Coolsculpting
  69. Response to “cryolipolysis: The Importance Of Scientific Evaluation of a New Technique”
  70. Noninvasive Body Contouring by Shock Waves And Cryolipolysis: A Clinical Study
  71. Clinical Efficacy of Fat Reduction on the Thigh of Korean Women Through Cryolipolysis
  72. Case Report Effects of Cryolipolysis on Abdominal Adiposity